ORIGINAL_ARTICLE
Assessment of serum Levels of Adiponectin and Leptin in a cohort of elderly Egyptian Patients with Dementia
Background/Aim: Dementia is a chronic progressive deterioration of cognitive function. About 50 million cases of dementia worldwide, 5-8% of elders aged 60 years and more have dementia. Adiponectin is an adipokine and presents in the humans’ brains and is linked to multiple functions in the central nervous system. Leptin is a cytokine that was thought to be associated with a decline in cognitive function. The present study aimed to assess adiponectin and leptin levels in elderly demented patients. Materials and methods: the current study included 60 subjects of both genders aged 65 years and more; Group (I): 40 patients with dementia, and Group (II): 20 healthy control subjects. We excluded participants with chronic renal or hepatic diseases, diabetics, hypertensive, dyslipidemic patients, those with thyroid disorders, and those who were morbidly obese. MMSE and MOCA tests were done on all subjects, levels of adiponectin and leptin were assessed in participants’ sera using the ELISA test. Results: Higher levels of adiponectin, but low levels of leptin were detected in patients with dementia. MMSE and MOCA scores were significantly correlated with serum adiponectin (negatively), and with serum leptin (positively). Conclusion: In elderly patients with dementia, serum adiponectin and leptin were strongly associated with the degree of dementia, which may help us to understand the underlying pathophysiology of this untreatable disease.
https://niles.journals.ekb.eg/article_150141_87c8c5d05416db2ca843d3c28f6ff039.pdf
2021-09-01
1
11
10.21608/niles.2021.60386.1048
adiponectin
leptin
Dementia
Elderly
Marwa
saad
marwa.saad@alexmed.edu.eg
1
internal medicine department, geriatric unit, faculty of medicine, Alexandria university, Alexandria, Egypt
LEAD_AUTHOR
mohamed
mehanna
mohamed.mehanna@alexmed.edu.eg
2
internal medicine department, geriatric unit, faculty of medicine , Alexandria university, Alexandria, Egypt
AUTHOR
samer
Hanna
physician@post.com
3
neurology department, faculty of medicine, Alexandria university, Alexandria, Egypt
AUTHOR
Dalia
Elneely
daliaelneely@yahoo.com
4
clinical pathology department, faculty of medicine, Alexandria university, Alexandria, Egypt
AUTHOR
ORIGINAL_ARTICLE
The clinical presentations and outcomes in a cohort of hospitalized elderly COVID-19 Egyptian patients: A cross-sectional study
Background and aims: Elders at an increased risk of getting the novel COVID-19 infection. Materials and Methods: We analyzed the clinical presentations, laboratory and radiological investigations, and the patient’s outcome in fifty seniors aged 60 years and more who were hospitalized due to COVID-19 confirmed by RT-PCR essay of nasopharyngeal swabs in the period from December 2020 till March 2021. Results: The mean age was 68.2 ± 5.9 years (60% males and 40% females), 70% with comorbidities. Our patients exhibited a variety of clinical manifestations (constitutional, respiratory, gastrointestinal, and atypical) and hematological presentations with variable percentages. The mean period of hospital stay was15.05 days with 60% of the patients cured and 40% died (60% males, 40% females). The causes of death were septic shock (81.8%), ARDS (36.3%), AKI (18.2%), DIC (13.6), and encephalitis (9.1%). Using multivariant regression analysis and Roc curve analysis; levels of D-dimer >901ng/ml, interleukin-6 >13.5pg/ml, and >30% lung involvement were independent predictors of mortality after adjustment of other predictors. Conclusion: Elderly patients are susceptible to adverse outcomes of SARS Cov-2 infection. Unexpectedly, gastrointestinal manifestations were associated with mortality in seniors along with low oxygen saturation, and wheezy chest. After multivariant regression analysis only D-dimer, interleukin-6, and the degree of lung involvement in CT were independent predictors of mortality in seniors after adjustment of other predictors.
https://niles.journals.ekb.eg/article_170332_e66cc39d23d12ff7d2b0a3169f89e549.pdf
2021-09-01
12
27
10.21608/niles.2021.75212.1054
SARS-CoV-2
Coronavirus
COVID-19
elderly patients
Outcome
Marwa
saad
marwa.saad@alexmed.edu.eg
1
internal medicine department, geriatric unit, faculty of medicine, Alexandria university, Alexandria, Egypt
LEAD_AUTHOR
Mohammed
Metwaly
yoyosoft2725@gmail.com
2
Alexandria Fever Hospital
AUTHOR
ORIGINAL_ARTICLE
Effectiveness Of Structured Teaching Program On Knowledge and Fear of Alzheimer's Disease in Cognitively Intact Older Adults
https://niles.journals.ekb.eg/article_187245_0883016325ebff45aa2ca83c17aad24c.pdf
2021-09-01
28
48
10.21608/niles.2021.187245
Eman
Meawad
1
Department of Gerontological Nursing, Faculty of Nursing, Mansoura University, Egypt
AUTHOR
Neamit
Elashri
2
Department of Gerontological Nursing, Faculty of Nursing, Mansoura University, Egypt
AUTHOR
Abdel-Hady
El-Gilany
3
Department of Public Health, Faculty of Medicine, Mansoura University, Egypt
AUTHOR
Raefa
Alam
4
Department of Gerontological Nursing, Faculty of Nursing, Mansoura University, Egypt
AUTHOR
ORIGINAL_ARTICLE
Relationship between C-Reactive Protein / Albumin Ratio and Coronary Artery Disease Severity in Patients with Chronic Coronary Syndromes
Background: Syntax score (SS), which is an angiographic technique used in categorizing the severity of coronary artery disease (CAD), has a significant prognosis in coronary artery disease (CAD) and explain an important information concerning selection of revascularization policy. C-reactive protein (CRP) and albumin are markers of inflammation, and high levels of them are associated with high SS. Aim of the Work: To detect whether baseline CRP to albumin ratio (CAR), an easily available and novel inflammatory indicator, is associated with SS in patients with chronic coronary syndromes. Methodology: This study was carried out on 100 patients having chronic coronary syndromes for whom, a diagnostic coronary angiography was done at Sohag University Cath. Lab unit in the period from January -July 2021. Patients were divided randomly into two equal groups:*Group I, patients having low SS (≤22). *Group II, patients having intermediate-high SS (>22).Results: C-Reactive Protein/Albumin Ratio was significantly higher in patients having intermediate-high SS group (P < .0001). In multivariate regression analysis, CAR was an independent indicator of intermediate-high SS group together with LDL. Conclusion: CAR was more intensely related to the severity of CAD than CRP and albumin alone and was detected to be an independent indicator for intermediate- high SS group.
https://niles.journals.ekb.eg/article_191878_64d57609944ab7fe7d8017cf9cadbc22.pdf
2021-09-01
49
57
10.21608/niles.2021.88465.1056
albumin
coronary artery disease severity
C-reactive protein
C-reactive protein/albumin ratio
Chronic coronary syndromes
Alaa
Ghaleb
alaaghalib10@yahoo.com
1
Internal Medicine
Sohag university
LEAD_AUTHOR
Ahmed
Boghdady
ahbomed@yahoo.com
2
Sohag Faculty of Medicine, Internal Medicine Department
AUTHOR
Mohammed
Shehab
mshehab404@yahoo.com
3
Sohag Faculty of Medicine, Internal Medicine Department
AUTHOR
Usama Mohammed
Abd Elaal
osamelaal74@yahoo.com
4
Sohag Faculty of Medicine, Internal Medicine Department
AUTHOR
ORIGINAL_ARTICLE
Telemedicine Assistance for Cardiac Patients in Egypt during COVID-19 Pandemic
Background: During the 2019 novel coronavirus (COVID-19) period, most of the countries were locked down and most of the hospitals established for COVID-19 patients only. The idea of telemedicine and online clinic was necessary and a good solution for patients who cannot reach or afraid from contacting corona virus carriers at cardiology clinics or hospitals. This study was conducted to assess the value of telemedicine in cardiac patients care and ease managing their chronic illness during COVID-19. Methodology: A cross sectional study during the course of one month of tele monitoring (from 5 July to 4 August), we received 2003 alerts (phone calls and messages). We used to communicate with patients on time or shortly within 24 hours according to their complaints.Results: As regard onset of complaint, 14.4% were acute onset and 85.6% were gradual onset. Recommendation for admission for only 15.1% and 84.9% of patients advised to continue treatment at home with some changes in doses.Conclusion:Telemedicine had a lot of economic and social benefits and it is a good solution especially in certain circumstances like the COVID-19 outbreak. It allows better follow-up, stimulation of self-management of the illness, improvement of quality of life, reduction of rehospitalization costs, and faster treatment in cardiac emergencies.
https://niles.journals.ekb.eg/article_192881_1fc3b922d5203f47eaa947d13c9e87cc.pdf
2021-09-01
58
64
10.21608/niles.2021.93546.1058
Telemedicine Assistance
COVID19
Cardiac patients
Alaa
Ghaleb
alaaghalib10@yahoo.com
1
Department of Internal Medicine ,Faculty of Medicine , Sohag University , Sohag, Egypt
LEAD_AUTHOR
Gamela
Nasr
gam_nasr@yahoo.com
2
Department of cardiology, Faculty of Medicine , Suez canal University, Ismailia , Egypt
AUTHOR
Seham
Abokresha
sehamghalib@yahoo.com
3
Department of Public Health and Community Medicine, Faculty of Medicine, Sohag University , Sohag , Egypt
AUTHOR
Sharaf E.D
Mahmoud
sharaf003@gmail.com
4
Department of Cardiology, Faculty of Medicine , Sohag University, Sohag, Egypt
AUTHOR