Relationship between C-Reactive Protein / Albumin Ratio and Coronary Artery Disease Severity in Patients with Chronic Coronary Syndromes

Document Type : Original Article

Authors

1 Internal Medicine Sohag university

2 Sohag Faculty of Medicine, Internal Medicine Department

Abstract

Background: Syntax score (SS), which is an angiographic technique used in categorizing the severity of coronary artery disease (CAD), has a significant prognosis in coronary artery disease (CAD) and explain an important information concerning selection of revascularization policy. C-reactive protein (CRP) and albumin are markers of inflammation, and high levels of them are associated with high SS.
Aim of the Work: To detect whether baseline CRP to albumin ratio (CAR), an easily available and novel inflammatory indicator, is associated with SS in patients with chronic coronary syndromes.
Methodology: This study was carried out on 100 patients having chronic coronary syndromes for whom, a diagnostic coronary angiography was done at Sohag University Cath. Lab unit in the period from January -July 2021. Patients were divided randomly into two equal groups:
*Group I, patients having low SS (≤22).
*Group II, patients having intermediate-high SS (>22).
Results: C-Reactive Protein/Albumin Ratio was significantly higher in patients having intermediate-high SS group (P < .0001). In multivariate regression analysis, CAR was an independent indicator of intermediate-high SS group together with LDL.
Conclusion: CAR was more intensely related to the severity of CAD than CRP and albumin alone and was detected to be an independent indicator for intermediate- high SS group.

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