Predictive Value of Serum Albumin in Patients with Acute Coronary Syndrome

Document Type : Original Article

Authors

1 Cardiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt

2 Internal Medicine Department, Faculty of Medicine, Sohag University, Sohag, Egypt

Abstract

Background: In patients with acute coronary syndrome (ACS), the presence of hypoalbuminemia has been associated with increased severity of coronary lesions, no-reflow, increased in-hospital, and long-term mortality as well as development of heart failure. Our study aimed to investigate the predictive value of serum albumin and short-term mortality in patients with ACS.
Methods: This prospective cohort study was carried out on patients who were admitted to the emergency department or coronary care unit with a diagnosis of ACS.
Results: Serum albumin can significantly predict mortality at cut-off 3.34 with 71.4% sensitivity, 62% specificity, 33.3% positive predictive value (PPV), 89.1% negative predictive value (NPV) and 64% accuracy (P value= 0.006). Serum albumin can significantly predict the mortality at cut-off 3.44 with 76.2% sensitivity, 57% specificity, 32% PPV, 90% NPV and 61% accuracy (P value= 0.007).
Conclusions: Serum albumin at cut off 3.34 is a promising predictor of short-term mortality in ACS patients. These support the potential utility of serum albumin as a simple, cost-effective biomarker for identifying patients at higher risk of mortality following an ACS event. Furthermore, the study found that patients with hypoalbuminemia had significantly higher levels of creatinine and lower levels of high-density lipoprotein cholesterol, hemoglobin, and peak troponin I compared to the patients with normal serum albumin.

Keywords

NILES journal for Geriatric and Gerontology
Volume 8, Issue 4
September 2025
Pages 414-425

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