Changes in intraocular pressure after intravitreal injection of ranibizumab

SAIF, Mohamed Yasser Sayed; Abd El Hafez, Khaled Abd ElAziz; Fouad, Asmaa Mohamed

doi:10.21608/niles.2020.26776.1009

Changes in intraocular pressure after intravitreal injection of ranibizumab

Document Type : Original Article

Authors

¹ Ophthalmology department , Faculty of Medicine , Beni-Suef University

² NILES , Beni-Suef University

³ Faculty of medicine_Benisuef University

⁴ Faculty of medicine-BeniSuef University BeniSuef

10.21608/niles.2020.26776.1009

Abstract

The aim of this study was to detect changes in intraocular pressure(IOP) following initial intravitreal injection of antivascular endothelial growth factor agents anti-VEGF ranibizumab in patients presenting with macular edema due to diabetes mellitus (DM), age- related macular degeneration(ARMD) , retineal vein occlusion(RVO), and myopic choroidal neovascularization (CNV) .
Methods:In this study,a prospective analysis was conducted on 40 eyes of 40 patients. IOP was measured using a goldmann applanation tonometer before injection, 24 h, 1st and weekly up to 8 weeks after injection . Patients were scheduled for intravitreal injection of anti-VEGF ranibizumab (0.5 mg/0.05 ml) for the treatment of macular edema due to(DM), (RVO), (ARMD) ,and (CNV).
Results: It was fоund that there was a significant difference, but still within the normal range value in IOP measured 24 h after injection(14.2±3.54 mmHg and ranged from (9 : 22 mmHg)) compared to baseline (p = 0.001) . There was no significant difference between the IOP from 1 week up to 8W of ranibizumab injection.
Conclusion: This study confirms the results of previous studies that showed the safety of initial IV injection of anti-VEGF agents for IOP elevation in post-injection two monthes in non- glaucomatous patients.

Keywords

References

1.Saif ATS, Saif PS , El Deeb A. Role of amniotic membrane transplantation in symblepharon. Guoji Yanke Zazhi(Int Eye Sci) 2017;17(5):819-824

2.Nassar M, Saif M, Saif A, Saif P. Sensitivity and specificity of nassar color test in early detection of diabetic macular edema. Journal of Retina-Vitreous. 2016;24:109-113.

3.Amer, S. , Saif, M. , Saif, A. and Saif, P. (2014) Variations of Cup-to-Disc Ratio in Children. Open Journal of Ophthalmology, 4, 12-17. doi: 10.4236/ojoph.2014.41003.